Did you know?

50% of Heart Attack victims have normal cholesterol.1

That’s because multiple factors in addition to cholesterol are required to determine the underlying cause of Heart Attack.2

Beyond Cholesterol testing.
Beyond Plaque testing.

Finally, a blood test for the
leading cause of Heart Attacks:

Unstable Cardiac Lesion Rupture.
White Bracket

The PULS (Protein Unstable Lesion Signature) Test measures the most clinically-significant protein biomarkers that measure the body's immune system response to arterial injury.3

These injuries lead to the formation and progression of cardiac lesions which may become unstable and rupture, leading to cardiac event.

PULS Proteins
puls
Cholesterol
Cholesterol
PULS Comprehensive Cardiac Profile

What are Unstable Cardiac Lesions and how do they form?

Unstable Cardiac Lesions form within the artery wall over time, often without any signs or symptoms, through a process of continuous arterial injury and repair.4,5

Healthy artery wall

VS.

Artery wall with Unstable Cardiac Lesion in danger of rupturing

  • 1. Arterial Injury

  • 2. Cell Proliferation

  • 3. Stimulation of new blood Cells

  • 4. Cell Adhesion & Platelet Aggregation

  • 5. Cell Death

An unstable lesion begins to form when oxidized or damaged lipids bind and aggregate on the arterial surface, causing an injury.

PULS test results can help prevent a heart attack - starting now.

The PULS Test can provide your physician with valuable information that can be used to determine the most appropriate course of action according to clinical guidelines.

Start the conversation with your doctor

Take the first step towards better heart health.
Ask your doctor about the PULS Cardiac Test.

Request Testing Online

News & Articles

May 4th, 2017
PULS Cardiac Test Performance Data Measuring Endothelial Injury to Predict Acute Coronary Syndrome to be presented at 2017 American Heart Association Scientific Sessions
November 2nd, 2016
PULS Cardiac Test Wins 2016 ABBY Award for Innovation in Healthcare
October 3rd, 2016
GD Biosciences' PULS Cardiac Test Named a Finalist for 2016 Innovations in Healthcare ABBY Awards
References

1.) Sachdeva, et al. Lipid levels in patients hospitalized with coronary artery disease: An analysis of 136,905 hospitalizations in Get With The Guidelines. AHJ. 2009; 157; Issue 1
2.) Kromhout, et al. Prevention of Coronary Heart Disease by Diet and Lifestyle. Circulation. 2002; 105: 893-898
3.) Nolan, et al. Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test. Expert Opin Med Diagn. 2013 Mar;7; Issue 2:127-36.
4.) Stary, et al. A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis. Circulation.1995; 92: 1355-1374
5.) van der Wal, Becker. Atherosclerotic plaque rupture – pathologic basis of plaque stability and instability. Cardiovascular Research. 1999 Feb 1; 41; Issue 2.