CHD remains the leading cause of death and disability despite recent improvements in disease management.1,2

Current risk stratification tools that rely on traditional risk factors fail to accurately identify those who are at risk of a Heart Attack. In fact, over 50% of individuals presenting with a severe cardiac event have at most one risk factor or normal cholesterol levels.3

Beyond Cholesterol testing.
Beyond Plaque testing.

Unlike any other test for CHD.

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    Validated in a multi-ethnic population4

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    Outcome data demonstrates clinical utility in identifying at-risk patients5

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    Conforms to current ACC/AHA(ATP IV) guidelines6

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    Motivates patients to adhere to physician recommendations7

PULS is a breakthrough blood test that analyzes the biological processes related to the leading cause of myocardial infarction Coronary Heart Disease (CHD):

Unstable Cardiac Lesion Rupture

The Hidden Danger of Unstable Cardiac Lesions

Unstable Cardiac Lesions form over time, often without any signs or symptoms, through a process of continuous artertial injury and repair.

Healthy artery wall


Artery wall with Unstable Cardiac Lesion in danger of rupturing

  • 1. Arterial Injury

  • 2. Cell Proliferation

  • 3. Stimulation of new blood Cells

  • 4. Cell Adhesion & Platelet Aggregation

  • 5. Cell Death

An unstable lesion begins to form when oxidized or damaged lipids bind and aggregate on the arterial surface, causing an injury.

The PULS™ Test Clinical Validation In Diagnosing Unstable Cardiac Lesion Rupture

The ability to detect the Unstable Lesions that are likely to rupture prior to the cardiac event is crucial in the area of clinical prevention.

The PULS Test analyzes clinically-validated, multiplexed serum protein assays to measure proteins related to inflammation, apoptosis, thrombosis, vascular remodeling, and other processes underlying Unstable Cardiac Lesion formation and CHD development.

PULS Protein Biomarkers
Protein Biomarker

The Latest AHA Guidelines Recommend Conducting Formal Quantitative CHD Risk Assessments

A patient’s personalized 5-Year diagnosis and prognosis of Unstable Cardiac Lesion Rupture.

A calculated “Heart Age” which shows the patient’s Cardiac Risk Score relative to their Age and Gender group.

Case Studies


“Your PULS Cardiac Profile will indicate if your Absolute Risk Score is Low, Borderline, or Unfavorable. Your physician can then determine the most appropriate course of action based on clinical guidelines.”

Read More About Francis

Case Studies


“Your PULS Cardiac Profile will indicate if your Absolute Risk Score is Low, Borderline, or Unfavorable. Your physician can then determine the most appropriate course of action based on clinical guidelines.”

Read More About Francis

Physician Testimonials

I recommend the PULS Cardiac Test as a non-invasive way to detect the underlying causes of Heart Disease early-on, when prevention is most effective. Dr. Michael Wong
Cardiologist, HeartCare Founder of Lipidologists of Los Angeles, Fellow of the American Hear Association, Member of the American Heart Association Speakers Burequ
Traditional tests tend to only detect disease when it is well established, leaving a large proportion of people at risk. The PULS Cardiac Test has been shown to effectively detect the initial arterial injury that leads to the vast majority of cardiac events. To me, this is a ‘game-changer’ that allows for a variety of safe and natural methods to prevent disease from leading to a Heart Attack. Dr. Nyjon Eccles, BSc MBBS MRCP PhD
Medical Director at The Natural Doctor, HB Health, Renaissance Medical, CHART
“Despite advances in Heart Attack prevention, there are still hundreds of thousands in the US who die each year, without warning, from Heart Disease. Half of those who suffer Heart Attacks have normal cholesterol. The PULS Cardiac Test is a tool that identifies patients, even at a young age, who are likely to have a Heart Attack, though they may not have any signs or symptoms.” Dr. Americo Simonini
Cardiologist, Cedars Sinai Heart Institute & Fellow of the American College of Cardiology

Order PULS

PULS is a simple blood test that may be performed for patients 40 years or older who have no previous history of a myocardial infarction.


1.) Murphy, et al. Deaths: Final Data for 2010. National Vital Statistics Reports, 2013; 61; Issue 4
2.) "The Top 10 Causes of Death." WHO. World Health Organization, 1 May 2014. Web. 10 Mar. 2015.
3.) Sachdeva, et al. Lipid levels in patients hospitalized with coronary artery disease: An analysis of 136,905 hospitalizations in Get With The Guidelines. AHJ. 2009; 157; Issue 1
4.) Cross, et al. Coronary risk assessment among intermediate risk patients using a clinical and biomarker based algorithm developed and validated in two population cohorts. Curr Med Res Opin. 2012 Nov;28; Issue 11:1819-30
5.) Nolan, et al. Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test. Expert Opin Med Diagn. 2013 Mar;7; Issue 2:127-36.
6.) Fleisher, et al. 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2014; 64; Issue 22
7.) *Based on physician and patient testimonials.
8.) Stary, et al. A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis. Circulation.1995; 92: 1355-1374
9.) van der Wal, Becker. Atherosclerotic plaque rupture – pathologic basis of plaque stability and instability. Cardiovascular Research. 1999 Feb 1; 41; Issue 2.