CHD remains the leading cause of death and disability despite recent improvements in disease management.1,2
Current risk stratification tools that rely on traditional risk factors fail to accurately identify those who are at risk of a Heart Attack. In fact, over 50% of individuals presenting with a severe cardiac event have at most one risk factor or normal cholesterol levels.3
Beyond Cholesterol testing.
Beyond Plaque testing.
Unlike any other test for CHD.
Validated in a multi-ethnic population4
Outcome data demonstrates clinical utility in identifying at-risk patients5
Conforms to current ACC/AHA(ATP IV) guidelines6
Motivates patients to adhere to physician recommendations7
PULS is a breakthrough blood test that analyzes the biological processes related to the leading cause of myocardial infarction Coronary Heart Disease (CHD):
Unstable Cardiac Lesion Rupture
The Hidden Danger of Unstable Cardiac Lesions
Unstable Cardiac Lesions form over time, often without any signs or symptoms, through a process of continuous artertial injury and repair.
Healthy artery wall
VS.
Artery wall with Unstable Cardiac Lesion in danger of rupturing
An unstable lesion begins to form when oxidized or damaged lipids bind and aggregate on the arterial surface, causing an injury.
The PULS™ Test Clinical Validation In Diagnosing Unstable Cardiac Lesion Rupture
The ability to detect the Unstable Lesions that are likely to rupture prior to the cardiac event is crucial in the area of clinical prevention.
The PULS Test analyzes clinically-validated, multiplexed serum protein assays to measure proteins related to inflammation, apoptosis, thrombosis, vascular remodeling, and other processes underlying Unstable Cardiac Lesion formation and CHD development.
PULS Protein Biomarkers

The Latest AHA Guidelines Recommend Conducting Formal Quantitative CHD Risk Assessments
A patient’s personalized 5-Year diagnosis and prognosis of Unstable Cardiac Lesion Rupture.
A calculated “Heart Age” which shows the patient’s Cardiac Risk Score relative to their Age and Gender group.
PULS Profile
A patient’s personalized 5-Year diagnosis and prognosis of Unstable Cardiac Lesion Rupture.
Heart Age
A calculated “Heart Age” which shows the patient’s Cardiac Risk Score relative to their Age and Gender group.
Lifestyle Changes
Specific recommendations for reducing risk according to clinical guidelines.
Case Studies
Francis
“Your PULS Cardiac Profile will indicate if your Absolute Risk Score is Low, Borderline, or Unfavorable. Your physician can then determine the most appropriate course of action based on clinical guidelines.”
Read More About FrancisCase Studies
Jose
“Your PULS Cardiac Profile will indicate if your Absolute Risk Score is Low, Borderline, or Unfavorable. Your physician can then determine the most appropriate course of action based on clinical guidelines.”
Read More About FrancisPhysician Testimonials
Order PULS
PULS is a simple blood test that may be performed for patients 40 years or older who have no previous history of a myocardial infarction.
References
1.) Murphy, et al. Deaths: Final Data for 2010. National Vital Statistics Reports, 2013; 61; Issue 4
2.) "The Top 10 Causes of Death." WHO. World Health Organization, 1 May 2014. Web. 10 Mar. 2015.
3.) Sachdeva, et al. Lipid levels in patients hospitalized with coronary artery disease: An analysis of 136,905 hospitalizations in Get With The Guidelines. AHJ. 2009; 157; Issue 1
4.) Cross, et al. Coronary risk assessment among intermediate risk patients using a clinical and biomarker based algorithm developed and validated in two population cohorts. Curr Med Res Opin. 2012 Nov;28; Issue 11:1819-30
5.) Nolan, et al. Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test. Expert Opin Med Diagn. 2013 Mar;7; Issue 2:127-36.
6.) Fleisher, et al. 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2014; 64; Issue 22
7.) *Based on physician and patient testimonials.
8.) Stary, et al. A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis. Circulation.1995; 92: 1355-1374
9.) van der Wal, Becker. Atherosclerotic plaque rupture – pathologic basis of plaque stability and instability. Cardiovascular Research. 1999 Feb 1; 41; Issue 2.
Latest News
Fox Business News highlights the PULS Cardiac Test as a warning sign to detect the early stages of endothelial injury for improved prevention of heart attacks.